Article
Drosophila Mgr, a Prefoldin subunit cooperating with von Hippel Lindau to regulate tubulin stability.
Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2012
Delgehyr Nathalie, Wieland Uta, Rangone Hélène, Pinson Xavier, Mao Guojie, Dzhindzhev Nikola S, McLean Doris, Riparbelli Maria G, Llamazares Salud, Callaini Giuliano, Gonzalez Cayetano, Glover David M
Abstract excerpt
Mutations in Drosophila merry-go-round (mgr) have been known for over two decades to lead to circular mitotic figures and loss of meiotic spindle integrity. However, the identity of its gene product has remained undiscovered. We now show that mgr encodes the Prefoldin subunit counterpart of human von Hippel Lindau binding-protein 1. Depletion of Mgr from cultured cells also leads to formation of monopolar and...
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