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Article

Role of N-Linked Glycosylation of the 5-HT <sub>2A</sub> Receptor in JC Virus Infection

22 Jul 2010

Abstract excerpt

JC virus (JCV) is a human polyomavirus and the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). JCV infection of host cells is dependent on interactions with cell surface asparagine (N)-linked sialic acids and the serotonin 5-hydroxytryptamine(2A) receptor (5-HT(2A)R). The 5-HT(2A)R contains five potential N-linked glycosylation sites on the extracellular N...

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PMID: 20660194
DOI: 10.1128/jvi.00978-10

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