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Transgenerational Glucose Intolerance With <i>Igf2</i>/<i>H19</i> Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia

24 Mar 2012

Abstract excerpt

Gestational diabetes mellitus (GDM) has been shown to be associated with high risk of diabetes in offspring. However, the mechanisms involved and the possibilities of transgenerational transmission are still unclear. We intercrossed male and female adult control and first-generation offspring of GDM (F1-GDM) mice to obtain the second-generation (F2) offspring in four groups: C♂-C♀, C♂-GDM♀, GDM♂-C♀, and...

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Share to Epigenetics and DNA Methylation
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PMID: 22447856
DOI: 10.2337/db11-1314

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