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Article

Cd14 SNPs regulate the innate immune response.

Molecular immunology - 1 Jun 2012

Liu Hong-Hsing, Hu Yajing, Zheng Ming, Suhoski Megan M, Engleman Edgar G, Dill David L, Hudnall Matt, Wang Jianmei, Spolski Rosanne, Leonard Warren J, Peltz Gary

Abstract excerpt

CD14 is a monocytic differentiation antigen that regulates innate immune responses to pathogens. Here, we show that murine Cd14 SNPs regulate the length of Cd14 mRNA and CD14 protein translation efficiency, and consequently the basal level of soluble CD14 (sCD14) and type I IFN production by murine macrophages. This has substantial downstream consequences for the innate immune response; the level of expression of...

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Identifiers

PMID: 22445606
DOI: 10.1016/j.molimm.2012.02.112
PMCID: PMC3341513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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