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Article

Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis.

The Journal of allergy and clinical immunology - 1 May 2012

Rebane Ana, Zimmermann Maya, Aab Alar, Baurecht Hansjörg, Koreck Andrea, Karelson Maire, Abram Kristi, Metsalu Tauno, Pihlap Maire, Meyer Norbert, Fölster-Holst Regina, Nagy Nikoletta, Kemeny Lajos, Kingo Külli, Vilo Jaak, Illig Thomas, Akdis Mübeccel, Franke Andre, Novak Natalija, Weidinger Stephan, Akdis Cezmi A

Abstract excerpt

BACKGROUND: Enhanced apoptosis of keratinocytes is the main cause of eczema and spongiosis in patients with the common inflammatory skin disease atopic dermatitis (AD). OBJECTIVE: The aim of the study was to investigate molecular mechanisms of AD-related apoptosis of keratinocytes. METHODS: Primary keratinocytes isolated from patients with AD and healthy donors were used to study apoptosis by using annexin...

Read the complete abstract on PubMed

Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22445417
DOI: 10.1016/j.jaci.2012.02.020

Genes

ADM
CCL5
CCL8
DUSP1
IFITM1
RAB31
IFI35
IFITM2
LYN
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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