Article
Inhibiting Tankyrases sensitizes KRAS-mutant cancer cells to MEK inhibitors via FGFR2 feedback signaling.
Cancer research - 15 Jun 2014
Schoumacher Marie, Hurov Kristen E, Lehár Joseph, Yan-Neale Yan, Mishina Yuji, Sonkin Dmitriy, Korn Joshua M, Flemming Daisy, Jones Michael D, Antonakos Brandon, Cooke Vesselina G, Steiger Janine, Ledell Jebediah, Stump Mark D, Sellers William R, Danial Nika N, Shao Wenlin
Abstract excerpt
Tankyrases (TNKS) play roles in Wnt signaling, telomere homeostasis, and mitosis, offering attractive targets for anticancer treatment. Using unbiased combination screening in a large panel of cancer cell lines, we have identified a strong synergy between TNKS and MEK inhibitors (MEKi) in KRAS-mutant cancer cells. Our study uncovers a novel function of TNKS in the relief of a feedback loop induced by MEK...
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