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Article

Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma.

International journal of colorectal disease - 1 Nov 2012

Knösel Thomas, Chen Yuan, Hotovy Stefanie, Settmacher Utz, Altendorf-Hofmann Annelore, Petersen Iver

Abstract excerpt

BACKGROUND: Genomewide expression profiling has identified a number of genes differentially expressed in colorectal carcinomas (CRCs) compared to normal tissue. Some of these genes were linked to epithelial-mesenchymal transition. We tested whether genes including desmocollins and homeobox genes were distinct on the protein level and correlated the expression with clinicopathological data. METHODS: Tissue...

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Source

Identifiers

PMID: 22438068
DOI: 10.1007/s00384-012-1460-4

Genes

DSC1
PITX1
CDX2
DSC2
CDK4
DSC3
MDM2
TLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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