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Epigenetic inactivation of endothelin‐2 and endothelin‐3 in colon cancer

3 Aug 2012

Abstract excerpt

Endothelin-1 (ET-1) and its receptors are overexpressed in human cancers, but much less is known about the roles of ET-2 and ET-3 in cancer etiology. We sought to examine human and rat colon tumors for dysregulation of ET-2 and ET-3 expression and determine the underlying mechanisms. Human primary colon cancers and carcinogen-induced rat colon tumors were subjected to real-time RT-PCR, immunoblotting and...

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PMID: 22865632
DOI: 10.1002/ijc.27762

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