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The aberrant methylation of <i>TSP1</i> suppresses TGF‐β1 activation in colorectal cancer

18 Apr 2008

Abstract excerpt

Colorectal cancer arises from the progressive accumulation of mutations and epigenetic alterations in colon epithelial cells. Such alterations often deregulate signaling pathways that affect the formation of colon cancer, such as the Wnt, RAS-MAPK and TGF-beta pathways. The tumor promoting effects of mutations in genes, such as APC, have been demonstrated in cancer cell lines and in mouse models of intestinal...

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Share to Epigenetics and DNA Methylation
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PMID: 18425817
DOI: 10.1002/ijc.23608

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