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Tuberous sclerosis and epilepsy: Role of astrocytes

21 Mar 2012

Abstract excerpt

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is among the most common genetic causes of epilepsy. Focal brain lesions in TSC, known as cortical tubers, have been implicated in promoting epileptogenesis in TSC. Histological, cellular, and molecular abnormalities in astrocytes are characteristic features of tubers and perituberal cortex, suggesting that astrocyte dysfunction may...

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PMID: 22438024
DOI: 10.1002/glia.22326

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