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Article

Tuberous sclerosis: a primary pathology of astrocytes?

Epilepsia - 1 Jan 2008

Sosunov Alexander A, Wu Xiaoping, Weiner Howard L, Mikell Charles B, Goodman Robert R, Crino Peter D, McKhann Guy M

Abstract excerpt

PURPOSE: Cortical tubers are epileptogenic lesions in patients with tuberous sclerosis complex (TSC). Giant cells and dysplastic neurons are pathological hallmarks of cortical tubers. Severe astrogliosis, which is invariably present in tubers, has attracted much less attention. We hypothesize that the development of astrogliosis in cortical tubers constitutes a primary pathology of astrocytes and is directly...

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Identifiers

PMID: 18226172
DOI: 10.1111/j.1528-1167.2008.01493.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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