Article

mTORC1 activation drives astrocyte reactivity in cortical tubers and brain organoid models of TSC

2025-03-05

Abstract excerpt

Tuberous Sclerosis Complex (TSC) is a genetic neurodevelopmental disorder associated with early onset epilepsy, intellectual disability and neuropsychiatric disorders. A hallmark of the disorder is cortical tubers, which are focal malformations of brain development containing dysplastic cells with hyperactive mTORC1 signaling. One barrier to developing therapeutic approaches and understanding the origins of tuber...

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Literature Corpus work: 92182166-4f4a-5cfb-9005-76d17dd51c2d
DOI: 10.1101/2025.02.28.640914

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