Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tuberous sclerosis complex and epilepsy: recent developments and future challenges.

Epilepsia - 1 Apr 2007

Holmes Gregory L, Stafstrom Carl E

Abstract excerpt

Tuberous sclerosis complex (TSC) is a congenital syndrome characterized by the widespread development of benign tumors in multiple organs, caused by mutations in one of the tumor suppressor genes, TSC1 or TSC2. About 80% of affected patients have a new mutation, and the remaining 20% have inherited a TSC gene mutation from a parent. The disorder affects approximately 1 in 6000 individuals. Cortical tubers are the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Anticonvulsants
Share to Clinical Protocols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Consensus

Share to Epilepsy

Share to Genes, Tumor Suppressor

Share to Research Design

Share to Tuberous Sclerosis

Source

Identifiers

PMID: 17386056
DOI: 10.1111/j.1528-1167.2007.01035.x

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tuberous sclerosis complex and epilepsy: recent developments and future challenges.PMID 17386056Read ↗

Brain Symptoms of Tuberous Sclerosis Complex: Pathogenesis and Treatment.Semantic proximity Read ↗

Epilepsy in Tuberous Sclerosis: Phenotypes, Mechanisms, and Treatments.Semantic proximity Read ↗

Topical Review: Intractable Seizures in Tuberous Sclerosis Complex: From Molecular Pathogenesis to the Rationale for TreatmentSemantic proximity Read ↗

Revisiting Brain Tuberous Sclerosis Complex in Rat and Human: Shared Molecular and Cellular Pathology Leads to Distinct Neurophysiological and Behavioral Phenotypes.Semantic proximity Read ↗

Tuberous sclerosis complex: From molecular biology to novel therapeutic approaches.Semantic proximity Read ↗

Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis ComplexSemantic proximity Read ↗

Tuberous sclerosis and epilepsy: Role of astrocytesSemantic proximity Read ↗

Epilepsy secondary to tuberous sclerosis: lessons learned and current challenges.Semantic proximity Read ↗

Therapeutic Approaches to Tuberous Sclerosis Complex: From Available Therapies to Promising Drug TargetsSemantic proximity Read ↗

Autism Spectrum Disorders in Tuberous Sclerosis: Pathogenetic Pathways and Implications for TreatmentSemantic proximity Read ↗

Brain lesions in tuberous sclerosis complex. Review.Semantic proximity Read ↗

Tuberous sclerosis complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.