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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

23 Mar 2012

Abstract excerpt

The multifunctional HIV-1 enzyme integrase interacts with viral DNA and its key cellular cofactor LEDGF to effectively integrate the reverse transcript into a host cell chromosome. These interactions are crucial for HIV-1 replication and present attractive targets for antiviral therapy. Recently, 2-(quinolin-3-yl) acetic acid derivatives were reported to selectively inhibit the integrase-LEDGF interaction in...

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PMID: 22437836
DOI: 10.1074/jbc.m112.354373

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