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HIV Integrase, a Brief Overview from Chemistry to Therapeutics

1 Jun 2001

Abstract excerpt

human immunodeficiency virus avian sarcoma virus Retroviruses are a large and diverse family of RNA viruses that synthesize a DNA copy of their RNA genome after infection of the host cell. Integration of this viral DNA into host DNA is an essential step in the replication cycle of HIV1 and other retroviruses (reviewed in Refs. 1Brown P.O. Coffin J.M. Hughes S.H. Varmus H.E. Retroviruses.in: Hughes J.M. Varmus...

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PMID: 11346660
DOI: 10.1074/jbc.r100027200

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