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Article

Blood mitochondrial DNA mutations in HIV-infected women and their infants exposed to HAART during pregnancy.

AIDS (London, England) - 27 Mar 2012

Jitratkosol Marissa H J, Sattha Beheroze, Maan Evelyn J, Gadawski Izabelle, Harrigan P Richard, Forbes John C, Alimenti Ariane, van Schalkwyk Julie, Money Deborah M, Côté Hélène C F

Abstract excerpt

OBJECTIVES: Nucleo(s/t)ide reverse transcriptase inhibitors given to HIV-infected pregnant women to prevent vertical transmission may adversely affect mitochondrial DNA (mtDNA). We hypothesized that HAART-exposed/HIV-uninfected infants may show higher blood mtDNA mutation burden than controls born to HIV-uninfected mothers. METHODS: Blood was collected from in-utero HIV/HAART-exposed infants and controls, as well...

Read the complete abstract on PubMed

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Share to Antiretroviral Therapy, Highly Active
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Infectious Disease Transmission, Vertical

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Share to Pregnancy Complications, Infectious

Share to Prenatal Exposure Delayed Effects

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Source

Identifiers

PMID: 22436539
DOI: 10.1097/QAD.0b013e32835142eb

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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