Article
The genomic features that affect the lengths of 5' untranslated regions in multicellular eukaryotes.
BMC bioinformatics - 5 Oct 2011
Chen Chun-Hsi, Lin Hsuan-Yu, Pan Chia-Lin, Chen Feng-Chi
Abstract excerpt
BACKGROUND: The lengths of 5'UTRs of multicellular eukaryotes have been suggested to be subject to stochastic changes, with upstream start codons (uAUGs) as the major constraint to suppress 5'UTR elongation. However, this stochastic model cannot fully explain the variations in 5'UTR length. We hypothesize that the selection pressure on a combination of genomic features is also important for 5'UTR evolution. The...
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