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Article

Differential stability of thymidylate synthase 3'-untranslated region polymorphic variants regulated by AUF1.

The Journal of biological chemistry - 18 Aug 2006

Pullmann Rudolf, Abdelmohsen Kotb, Lal Ashish, Martindale Jennifer L, Ladner Robert D, Gorospe Myriam

Abstract excerpt

A 6-nucleotide insertion (I)/deletion (D) polymorphism in the 3'-untranslated region of the thymidylate synthase gene was shown to influence mRNA stability, but the molecular basis of this effect has not been elucidated. Here, studies of both endogenous and ectopically expressed thymidylate synthase alleles revealed that the mRNA-binding, decay-promoting protein AUF1 has higher affinity for allele D mRNA. AUF1...

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PMID: 16787927
DOI: 10.1074/jbc.M600282200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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