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Article

Regio- and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants.

Angewandte Chemie (International ed. in English) - 20 Jul 2020

Li Aitao, Acevedo-Rocha Carlos G, D'Amore Lorenzo, Chen Jinfeng, Peng Yaqin, Garcia-Borràs Marc, Gao Chenghua, Zhu Jinmei, Rickerby Harry, Osuna Sílvia, Zhou Jiahai, Reetz Manfred T

Abstract excerpt

Steroidal C7β alcohols and their respective esters have shown significant promise as neuroprotective and anti-inflammatory agents to treat chronic neuronal damage like stroke, brain trauma, and cerebral ischemia. Since C7 is spatially far away from any functional groups that could direct C-H activation, these transformations are not readily accessible using modern synthetic organic techniques. Reported here are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32243054
DOI: 10.1002/anie.202003139
PMCID: PMC7384163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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