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Article

Heterozygous variants in DOCK2 leading to susceptibility to viral illnesses.

The Journal of allergy and clinical immunology - 1 Jun 2026

Al-Musa Amer, Platt Craig, Elkins Megan, Novak Tanya, Woods Brian, Bourdine Aleksandra, Magin Logan, Craiglow Brittany G, Newhams Margaret M, Kong Michele, Randolph Adrienne, Chou Janet

Abstract excerpt

BACKGROUND: Inborn errors of immunity are classically identified in infants and young children with severe or recurrent infections. However, hypomorphic variants with a partial loss of function can remain unrecognized until later in life and may underlie clinically significant susceptibility to infections in previously healthy individuals. OBJECTIVE: We sought to investigate how 3 novel heterozygous variants in...

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Source

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Identifiers

PMID: 41654261
DOI: 10.1016/j.jaci.2026.01.026
PMCID: PMC13016768

Genes

DOCK2
ELMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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