Article
Aging Kit mutant mice develop cardiomyopathy.
PloS one - 1 Jan 2012
Ye Lei, Zhang Eric Yang, Xiong Qiang, Astle Clinton M, Zhang Pengyuan, Li Qinglu, From Arthur H L, Harrison David E, Zhang Jianyi Jay
Abstract excerpt
Both bone marrow (BM) and myocardium contain progenitor cells expressing the c-Kit tyrosine kinase. The aims of this study were to determine the effects of c-Kit mutations on: i. myocardial c-Kit(+) cells counts and ii. the stability of left ventricular (LV) contractile function and structure during aging. LV structure and contractile function were evaluated (echocardiography) in two groups of Kit mutant (W/Wv...
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