Article
Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature.
Journal of cell science - 1 Jul 2012
Solomon Hilla, Buganim Yosef, Kogan-Sakin Ira, Pomeraniec Leslie, Assia Yael, Madar Shalom, Goldstein Ido, Brosh Ran, Kalo Eyal, Beatus Tsevi, Goldfinger Naomi, Rotter Varda
Abstract excerpt
Concomitant expression of mutant p53 and oncogenic Ras, leading to cellular transformation, is well documented. However, the mechanisms by which the various mutant p53 categories cooperate with Ras remain largely obscure. From this study we suggest that different mutant p53 categories cooperate with H-Ras in different ways to induce a unique expression pattern of a cancer-related gene signature (CGS). The...
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