Article
Population growth enhances the mean fixation time of neutral mutations and the persistence of neutral variation.
Genetics - 1 Jun 2012
Waxman D
Abstract excerpt
A fundamental result of population genetics states that a new mutation, at an unlinked neutral locus in a randomly mating diploid population, has a mean time of fixation of ∼4N(e) generations, where N(e) is the effective population size. This result is based on an assumption of fixed population size, which does not universally hold in natural populations. Here, we analyze such neutral fixations in populations of...
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