Revisiting the time until fixation of a neutral mutant in a finite population - A coalescent theory approach.

Abstract excerpt

Evaluation of the time scale of the fixation of neutral mutations is crucial to the theoretical understanding of the role of neutral mutations in evolution. Diffusion approximations of the Wright-Fisher model are most often used to derive analytic formulations of genetic drift, as well as for the time scales of the fixation of neutral mutations. These approximations require a set of assumptions, most notably that...

Topics

• Gene Frequency
• Genetics, Population
• Markov Chains
• Models, Theoretical
• Mutation
• Stochastic Processes