Fixation probabilities when generation times are variable: the burst death model.

doi:10.1534/genetics.107.072009

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Article

Fixation probabilities when generation times are variable: the burst death model.

Genetics - 1 Jul 2007

Hubbarde J E, Wild G, Wahl L M

Abstract excerpt

Estimating the fixation probability of a beneficial mutation has a rich history in theoretical population genetics. Typically, to attain mathematical tractability, we assume that generation times are fixed, while the number of offspring per individual is stochastic. However, fixation probabilities are extremely sensitive to these assumptions regarding life history. In this article, we compute the fixation...

Topics

Genetics, Population
Models, Genetic
Mutation
Oncolytic Viruses
Probability
Virus Replication

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Open in PubMed Open full text

Identifiers

PMID: 17483420
DOI: 10.1534/genetics.107.072009
PMCID: PMC1931549

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