Article
Sodium fluoride does not increase human bone cell proliferation or protein synthesis in vitro.
Calcified tissue international - 1 Oct 1990
Kopp J B, Robey P G
Abstract excerpt
The efficacy of sodium fluoride therapy for osteoporosis remains controversial. Evidence from clinical studies and from animals receiving fluoride has suggested that fluoride might act on bone to increase osteoblast numbers and matrix synthesis. In order to examine the hypothesis that fluoride has a direct mitogenic or anabolic action on the osteoblast, we tested the effect of fluoride on first passage human...
Topics
- Aged
- Aged, 80 and over
- Bone Development
- Bone Matrix
- Bone and Bones
- Cell Division
- Cells, Cultured
- DNA
- Female
- Humans
- Male
- Middle Aged