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Article

MTHFR 677T is a strong determinant of the degree of hearing loss among Polish males with postlingual sensorineural hearing impairment.

DNA and cell biology - 1 Jul 2012

Pollak Agnieszka, Mueller-Malesinska Malgorzata, Lechowicz Urszula, Skorka Agata, Korniszewski Lech, Sobczyk-Kopciol Agnieszka, Waskiewicz Anna, Broda Grazyna, Iwanicka-Pronicka Katarzyna, Oldak Monika, Skarzynski Henryk, Płoski Rafał

Abstract excerpt

Hearing impairment (HI) is the most common sensory handicap. Congenital HI often has a genetic basis, whereas the etiology of nonsyndromic postlingual HI (npHI) usually remains unidentified. Our purpose was to test whether the MTHFR C677T (rs1801133) polymorphism affecting folate metabolism is associated with the occurrence or severity of npHI. We studied rs1801133 genotypes in 647 npHI patients (age <40, sudden...

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Source

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Identifiers

PMID: 22424391
DOI: 10.1089/dna.2012.1607
PMCID: PMC3391488

Genes

MTHFR

Variants

rs1801133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MTHFR 677T is a strong determinant of the degree of hearing loss among Polish males with postlingual sensorineural hearing impairment.PMID 22424391Read ↗

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