Article
Shaggy/glycogen synthase kinase 3β and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis.
Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2012
Takeo Satomi, Swanson Selene K, Nandanan Kavyasree, Nakai Yasuhiro, Aigaki Toshiro, Washburn Michael P, Florens Laurence, Hawley R Scott
Abstract excerpt
The Ca(2+)/Calmodulin-dependent phosphatase calcineurin is essential for exit from meiotic arrest at metaphases I and II in Drosophila and Xenopus oocytes. We previously found that Sarah, the Drosophila homolog of regulator of calcineurin, acts as a positive regulator of calcineurin and is required to complete anaphase I of female meiosis. Here, we undertook biochemical approaches, including MS and...
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