Article
Src64 controls a novel actin network required for proper ring canal formation in the Drosophila male germline.
Development (Cambridge, England) - 1 Dec 2015
Eikenes Åsmund Husabø, Malerød Lene, Lie-Jensen Anette, Sem Wegner Catherine, Brech Andreas, Liestøl Knut, Stenmark Harald, Haglund Kaisa
Abstract excerpt
In many organisms, germ cells develop as cysts in which cells are interconnected via ring canals (RCs) as a result of incomplete cytokinesis. However, the molecular mechanisms of incomplete cytokinesis remain poorly understood. Here, we address the role of tyrosine phosphorylation of RCs in the Drosophila male germline. We uncover a hierarchy of tyrosine phosphorylation within germline cysts that positively...
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