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Fibroblast Growth Factor 2 and Its Receptors in Bone Biology and Disease

28 May 2018

Abstract excerpt

The fibroblast growth factor (FGF) regulatory axis is phylogenetically ancient, evolving into a large mammalian/human gene family of 22 ligands that bind to four receptor tyrosine kinases for a complex physiologic system controlling cell growth, differentiation, and metabolism. The tissue targets for the primary FGF function are mainly in cartilage and in bone for morphogenesis, mineralization, and metabolism. A...

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PMID: 29942929
DOI: 10.1210/js.2018-00105

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