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Article

CTCF-binding sites within the H19 ICR differentially regulate local chromatin structures and cis-acting functions.

Epigenetics - 1 Apr 2012

Guibert Sylvain, Zhao Zhihu, Sjölinder Mikael, Göndör Anita, Fernandez Alejandro, Pant Vinod, Ohlsson Rolf

Abstract excerpt

It is generally assumed that CTCF-binding sites are synonymous with the demarcation of expression domains by promoting the formation of chromatin loops. We have proposed earlier, however, that such features may be context-dependent. In support of this notion, we show here that chromatin loop structures, impinging on CTCF-binding sites 1/2 and 3/4 at the 5' and 3'-ends, respectively, within the maternal allele of...

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Share to CCCTC-Binding Factor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22415163
DOI: 10.4161/epi.19487

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CTCF-binding sites within the H19 ICR differentially regulate local chromatin structures and cis-acting functions.PMID 22415163Read ↗

Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development.Semantic proximity Read ↗

Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance.Semantic proximity Read ↗

Analysis of the <i>H19ICR</i> InsulatorSemantic proximity Read ↗

CTCF binding at the <i>H19</i> imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to <i>Igf2</i>Semantic proximity Read ↗

Multiple Nucleosome Positioning Sites Regulate the CTCF-Mediated Insulator Function of the H19 Imprinting Control Region†Semantic proximity Read ↗

Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator functionSemantic proximity Read ↗

Assessment of the CTCF Binding Sites and Repeat-Positions Upstream the Human <i>H19</i> GeneSemantic proximity Read ↗

Novel cis-regulatory function in ICR-mediated imprinted repression of H19Semantic proximity Read ↗

A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele.Semantic proximity Read ↗

CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Role of CTCF binding sites in the Igf2/H19 imprinting control region.Semantic proximity Read ↗

CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region.Semantic proximity Read ↗

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