Article
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance.
Molecular and cellular biology - 1 Apr 2004
Pant Vinod, Kurukuti Sreenivasulu, Pugacheva Elena, Shamsuddin Shaharum, Mariano Piero, Renkawitz Rainer, Klenova Elena, Lobanenkov Victor, Ohlsson Rolf
Abstract excerpt
The differentially methylated imprinting control region (ICR) region upstream of the H19 gene regulates allelic Igf2 expression by means of a methylation-sensitive chromatin insulator function. We have previously shown that maternal inheritance of mutated (three of the four) target sites for the...
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