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Article

Analysis of the <i>H19ICR</i> Insulator

6 Mar 2007

Abstract excerpt

Transcriptional insulators are specialized cis-acting elements that protect promoters from inappropriate activation by distal enhancers. The H19 imprinting control region (ICR) functions as a CTCF-dependent, methylation-sensitive transcriptional insulator. We analyzed several insertional mutations and demonstrate that the ICR can function as a methylation-regulated maternal chromosome-specific insulator in novel...

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PMID: 17339341
DOI: 10.1128/mcb.02170-06

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Click a neighbor to travelStep 1 · 12 closest

Analysis of the <i>H19ICR</i> InsulatorPMID 17339341Read ↗

CTCF binding at the <i>H19</i> imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to <i>Igf2</i>Semantic proximity Read ↗

CTCF-binding sites within the H19 ICR differentially regulate local chromatin structures and cis-acting functions.Semantic proximity Read ↗

Three-dimensional conformation at the H19/Igf2 locus supports a model of enhancer trackingSemantic proximity Read ↗

Multiple Nucleosome Positioning Sites Regulate the CTCF-Mediated Insulator Function of the H19 Imprinting Control Region†Semantic proximity Read ↗

Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator functionSemantic proximity Read ↗

Novel cis-regulatory function in ICR-mediated imprinted repression of H19Semantic proximity Read ↗

The transcriptional status but not the imprinting control region determines allele-specific histone modifications at the imprinted H19 locus.Semantic proximity Read ↗

<i>H19</i> Imprinting Control Region Methylation Requires an Imprinted Environment Only in the Male Germ LineSemantic proximity Read ↗

Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Semantic proximity Read ↗

Establishment of paternal methylation imprint at the H19/Igf2 imprinting control region.Semantic proximity Read ↗

Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development.Semantic proximity Read ↗

Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting.Semantic proximity Read ↗

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