Hydroperoxidase I catalyzes peroxidative activation of 3,3'-dichlorobenzidine to a mutagen in Salmonella typhimurium.

doi:10.1016/0003-9861(90)90128-l

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Article

Hydroperoxidase I catalyzes peroxidative activation of 3,3'-dichlorobenzidine to a mutagen in Salmonella typhimurium.

Archives of biochemistry and biophysics - 1 Nov 1990

McGowan-Jordan I J, Josephy P D

Abstract excerpt

Dichlorobenzidine can be peroxidatively activated in Salmonella typhimurium Ames tester strains. Mutagenicity is observed when an S. typhimurium strain which is sensitive to frame-shift mutagens is incubated with dichlorobenzidine and hydrogen peroxide. In this paper, we show that the bacterial e...

Topics

3,3'-Dichlorobenzidine
Benzidines
Biotransformation
Catalase
Escherichia coli Proteins
Fluorenes
Hydrogen Peroxide
Mutagenicity Tests
Mutagens
Mutation
Oxidation-Reduction
Salmonella typhimurium

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