Article
Direct comparison of 3 PCR methods in detecting EGFR mutations in patients with advanced non-small-cell lung cancer.
Clinical lung cancer - 1 Sept 2012
Ikeda Takaya, Nakamura Yoichi, Yamaguchi Hiroyuki, Tomonaga Nanae, Doi Seiji, Nakatomi Katsumi, Iida Tetsuya, Motoshima Kohei, Mizoguchi Kosuke, Nagayasu Takeshi, Tsukamoto Kazuhiro, Kohno Shigeru
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) mutations are predictive of response to EGFR tyrosine kinase inhibitors (TKIs) in NSCLC. Several methods have been used to detect EGFR mutations; however, it is not clear which is the most suitable for use in the clinic. In this study, we directly compare the clinical sensitivity and specificity of 3 PCR methods. PATIENTS AND METHODS: We compared the 3 PCR...
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