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Article

Up-regulation of the betaine/GABA transporter BGT1 by JAK2.

Biochemical and biophysical research communications - 30 Mar 2012

Hosseinzadeh Zohreh, Shojaiefard Manzar, Bhavsar Shefalee K, Lang Florian

Abstract excerpt

Janus-activated kinase-2 JAK2 is activated by hyperosmotic shock and modifies the activity of several Na(+) coupled transporters. Carriers up-regulated by osmotic shock include the Na(+) coupled osmolyte transporter BGT1 (betaine/GABA transporter 1), which accomplishes the concentrative cellular uptake of γ-amino-butyric acid (GABA). The present study thus explored whether JAK2 participates in the regulation of...

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Source

Identifiers

PMID: 22405821
DOI: 10.1016/j.bbrc.2012.02.137

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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