Article
Identification of the second tonicity-responsive enhancer for the betaine transporter (BGT1) gene.
Biochimica et biophysica acta - 3 Sept 1999
Miyakawa H, Rim J S, Handler J S, Kwon H M
Abstract excerpt
When certain cells are exposed to a hypertonic solution, transcription of the BGT1 gene is markedly increased. The ensuing rise in betaine transport leads to cellular accumulation of betaine that protects the cells from the stress of hypertonicity. We have previously identified a tonicity-responsive enhancer (TonE1) in the 5' flanking region of the BGT1 gene. It was recognized, however, that full activation of...
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