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Article

The Prevalence of MYD88 L265P and TNFAIP3 Mutations and Their Correlations with Clinico-Hematological Profile in Egyptian Patients with Diffuse Large B Cell Lymphoma.

Asian Pacific journal of cancer prevention : APJCP - 1 Jul 2023

Elbaz Osama, Shaat Rana M, Abd El Ghaffar Hasan A, Shamaa Sameh, Abdel-Masseih Hanaa M, Anber Nahla, Mortada Metwaly Ibrahim

Abstract excerpt

BACKGROUND: Activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) is characterized by chronic active B-cell receptor signaling and a constitutive activation of the NF-KB pathway. MYD88 L265P mutation occurs as a driving force of NF-KB overactivity in ABC-DLBCL. Nonetheless, in cases of DLBCL, the MYD88 L265P mutation has not yet been investigated in association with the tumour necrosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37505783
DOI: 10.31557/APJCP.2023.24.7.2485
PMCID: PMC10676502

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