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Article

The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.

Neuroscience - 30 Jun 2010

Bertrand J, Plouffe V, Sénéchal P, Leclerc N

Abstract excerpt

Tau, an axonal microtubule-associated protein, becomes hyperphosphorylated in several neurodegenerative diseases including Alzheimer disease (AD). In AD brain, tau is phosphorylated at pathological multiple-site epitopes recognized by the antibodies AT8 (S199/S202/T205), AT100 (T212/S214/T217), AT180 (T231/S235) and PHF-1 (S396/S404) and at individual sites such as S262 and S422. Although it is believed that the...

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PMID: 20394726
DOI: 10.1016/j.neuroscience.2010.04.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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