Article
DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice.
Molecular brain - 6 Dec 2012
Pidsley Ruth, Fernandes Cathy, Viana Joana, Paya-Cano Jose L, Liu Lin, Smith Rebecca G, Schalkwyk Leonard C, Mill Jonathan
Abstract excerpt
BACKGROUND: Insulin-like growth factor 2 (Igf2) is a paternally expressed imprinted gene regulating fetal growth, playing an integral role in the development of many tissues including the brain. The parent-of-origin specific expression of Igf2 is largely controlled by allele-specific DNA methylation at CTCF-binding sites in the imprinting control region (ICR), located immediately upstream of the neighboring H19...
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