Article
Engineered oligomerization state of OmpF protein through computational design decouples oligomer dissociation from unfolding.
Journal of molecular biology - 25 May 2012
Naveed Hammad, Jimenez-Morales David, Tian Jun, Pasupuleti Volga, Kenney Linda J, Liang Jie
Abstract excerpt
Biogenesis of β-barrel membrane proteins is a complex, multistep, and as yet incompletely characterized process. The bacterial porin family is perhaps the best-studied protein family among β-barrel membrane proteins that allows diffusion of small solutes across the bacterial outer membrane. In this study, we have identified residues that contribute significantly to the protein-protein interaction (PPI) interface...
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