Article
Pesticide exposure and oxidative stress generation are linked to poor prognosis outcomes in breast cancer women carrying the allelic variant rs7438135 in the UGT2B7 gene.
Journal of biochemical and molecular toxicology - 1 Nov 2024
Vacario Beatriz Geovana Leite, da Silva Isabely Mayara, Machado Murilo Galvani, Orrutéa Julia Fernandes Gois, Campos Aline Graciele Henriques, Matos Rafaela Oliveira, Federige Ana Carolina Lopes, Koizumi Bruna Yukie, Leite Maikely Bruna, Komori Isabela Mitsu Suo, Dos Santos Jaques Hellen, Rech Daniel, Guembarovski Roberta Losi, Amarante Marla Karine, Serpeloni Juliana Mara, Panis Carolina
Abstract excerpt
Pesticide exposure is a risk factor for the development of several diseases, including breast cancer (BC). The enzyme UGT2B7 participate in detoxification of pesticides and the presence rs7438135 (G > A) variant in your gene increases its glucuronidation potential, contributing to oxidative stress metabolites neutralization. Here we investigated the impact of occupational pesticide exposure on the systemic...
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