Article
Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin.
Platelets - 1 Jan 2013
Kreutz Rolf P, Nystrom Perry, Kreutz Yvonne, Miao Jia, Kovacs Richard, Desta Zeruesenay, Flockhart David A, Jin Yan
Abstract excerpt
Diabetes mellitus (DM) is associated with increased platelet activation and reduced platelet inhibition by clopidogrel. Prostaglandin E1 (PGE1) stimulates adenyl cyclase activity in platelets and increases cyclic AMP concentrations, which inhibit Ca(2+)release and platelet aggregation induced by P2Y1 receptor activation. PGE1 is included in the VerifyNow P2Y12 assay to suppress P2Y1 induced platelet aggregation....
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