Longitudinal tracking of human fetal cells labeled with super paramagnetic iron oxide nanoparticles in the brain of mice with motor neuron disease.

doi:10.1371/journal.pone.0032326

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Article

Longitudinal tracking of human fetal cells labeled with super paramagnetic iron oxide nanoparticles in the brain of mice with motor neuron disease.

PloS one - 1 Jan 2012

Bigini Paolo, Diana Valentina, Barbera Sara, Fumagalli Elena, Micotti Edoardo, Sitia Leopoldo, Paladini Alessandra, Bisighini Cinzia, De Grada Laura, Coloca Laura, Colombo Laura, Manca Pina, Bossolasco Patrizia, Malvestiti Francesca, Fiordaliso Fabio, Forloni Gianluigi, Morbidelli Massimo, Salmona Mario, Giardino Daniela, Mennini Tiziana, Moscatelli Davide, Silani Vincenzo, Cova Lidia

Abstract excerpt

Stem Cell (SC) therapy is one of the most promising approaches for the treatment of Amyotrophic Lateral Sclerosis (ALS). Here we employed Super Paramagnetic Iron Oxide nanoparticles (SPIOn) and Hoechst 33258 to track human Amniotic Fluid Cells (hAFCs) after transplantation in the lateral ventricles of wobbler (a murine model of ALS) and healthy mice. By in vitro, in vivo and ex vivo approaches we found that: 1)...

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PMID: 22384217
DOI: 10.1371/journal.pone.0032326
PMCID: PMC3288077

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