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Article

Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling.

The Journal of biological chemistry - 10 May 2002

Geha Rani Maurice, Chen Kevin, Wouters Johan, Ooms Frederic, Shih Jean Chen

Abstract excerpt

Monoamine oxidase (MAO) is a key enzyme responsible for the degradation of serotonin, norepinephrine, dopamine, and phenylethylamine. It is an outer membrane mitochondrial enzyme existing in two isoforms, A and B. We have recently generated 14 site-directed mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397, Tyr-407, and Tyr-444, in MAO A and their corresponding amino acids in...

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Identifiers

PMID: 11861643
DOI: 10.1074/jbc.M110920200
PMCID: PMC2844881

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Source receipt: pubmed, retrieved 7 Sept 2026.

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