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Article

Influence of cytochrome P450 2C19 gene variations on pharmacokinetic parameters of thalidomide in Japanese patients.

Biological & pharmaceutical bulletin - 1 Jan 2012

Matsuzawa Naoki, Nakamura Katsunori, Matsuda Masayuki, Ishida Fumihiro, Ohmori Shigeru

Abstract excerpt

PURPOSE: Cytochrome P450 (CYP)2C19 polymorphisms may partly explain the variability of thalidomide concentration and adverse drug effects by altering its metabolism. To compare the genetic and clinical factors responsible for the adverse effects and efficacy of thalidomide treatment, we investigated CYP2C19 genetic polymorphisms in Japanese subjects. MATERIALS AND METHODS: Variations in the CYP2C19 gene in 6...

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Source

Identifiers

PMID: 22382316
DOI: 10.1248/bpb.35.317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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