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Article

Thrombin induces an inflammatory phenotype in a human brain endothelial cell line.

Journal of neuroimmunology - 1 Apr 2012

Alabanza Leah M, Bynoe Margaret S

Abstract excerpt

In this study, we utilized the human brain endothelial cell line, hCMEC/D3, to determine the effects of the coagulation factor, thrombin, on the human blood-brain barrier (BBB). We show that thrombin increased the mRNA and cell surface levels of ICAM-1 and VCAM-1 in hCMEC/D3 cells. Thrombin similarly upregulated several chemokines implicated in human neurological conditions. Additionally, the paracellular...

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Identifiers

PMID: 22381244
DOI: 10.1016/j.jneuroim.2012.02.004
PMCID: PMC3608467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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