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A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions

2016-01-21

Abstract excerpt

The aim of this study was to develop a three-dimensional (3D) model of the human blood-brain barrier in vitro , which mimics the cellular architecture of the CNS and could be used to analyse the delivery of nanoparticles to cells of the CNS. The model includes human astrocytes set in a collagen gel, which is overlaid by a monolayer of human brain endothelium (hCMEC/D3 cell line). The model was characterised by tr...

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Literature Corpus work
28704c22-39ec-5fe9-83f8-ffd31eabaf1e
DOI
10.12688/f1000research.7142.2
Open publication

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A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactionsDOI 10.12688/f1000research.7142.2
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