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Helicobacter pylori genotype and polymorphisms in DNA repair enzymes: where do they correlate in gastric cancer?

Journal of surgical oncology - 15 Sept 2012

Silva-Fernandes Isabelle Joyce de Lima, da Silva Thayse Azevedo, Agnez-Lima Lucymara Fassarella, Ferreira Márcia Valéria Pitombeira, Rabenhorst Silvia Helena Barem

Abstract excerpt

BACKGROUND AND OBJECTIVES: One of the mechanisms proposed by which H. pylori causes gastric cancer (GC) is through DNA damage due to chronic inflammation. Genomic integrity is guaranteed by repair enzymes such as APE-1, OGG-1, and PARP-1. Host genetic polymorphisms associated with the bacterial strain may influence the ability to repair the damage, contributing to the development of H. pylori-associated GC. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22374853
DOI: 10.1002/jso.23077

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