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Host repair polymorphisms and H. pylori genes in gastric disease outcomes: Who are the guardian and villains?

Gene - 15 Jan 2025

Maria de Oliveira Barboza Morgana, Ferreira da Costa Reginaldo, Paulo Por Deus Gomes João, Mário Rodríguez Burbano Rommel, Goberlânio de Barros Silva Paulo, Helena Barem Rabenhorst Silvia

Abstract excerpt

Gastric cancer (GC) is the fourth-leading cause of cancer-related mortality. The intestinal subtype of GC comes after the cascade of Correa, presenting H. pylori infection as the major etiological factor. One of the main mechanisms proposed for the progression from a more benign gastric lesion to cancer is DNA damage caused by chronic inflammation. Polymorphisms in DNA repair genes can lead to an imbalance of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 39389328
DOI: 10.1016/j.gene.2024.148977

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